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Regulating repetition: Gaining control of CAG repeats could slow progression of Huntington’s disease
December 2, 2023
“Somatic expansion” is a hot topic in Huntington’s disease research. Somatic expansion is a process in which CAG repeats lengthen in some cells during aging….
Beyond huntingtin lowering: out-of-the-box approaches for the treatment of HD
November 24, 2023
In recent years, HD research headlines have trended toward huntingtin lowering: experimental therapies that target the root genetic cause of HD. But there are also…
Getting to the Root of Huntington’s Disease: A Plant-Based Approach
October 16, 2023
Researchers studied a fragment of the Huntington’s disease (HD) protein in plants and found a new way to stop it from forming toxic clumps. A…
Could halting CAG expansions be a new treatment for HD?
October 6, 2023
A recent paper from a group at UMass Chan Medical School, spearheaded by Dr. Daniel O’Reilly and led by Dr. Anastasia Khvorova, used genetic strategies…
Tipping the balance; new insights into HD genetic modifiers
September 1, 2023
Genetic modifiers can influence when HD symptoms begin. Some of these genes encode for different types of molecular machines whose normal job is to repair…