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Beyond huntingtin lowering: out-of-the-box approaches for the treatment of HD
In recent years, HD research headlines have trended toward huntingtin lowering: experimental therapies that target the root genetic cause of HD. But there are also…
Getting to the Root of Huntington’s Disease: A Plant-Based Approach
Researchers studied a fragment of the Huntington’s disease (HD) protein in plants and found a new way to stop it from forming toxic clumps. A…
Could halting CAG expansions be a new treatment for HD?
A recent paper from a group at UMass Chan Medical School, spearheaded by Dr. Daniel O’Reilly and led by Dr. Anastasia Khvorova, used genetic strategies…
Tipping the balance; new insights into HD genetic modifiers
Genetic modifiers can influence when HD symptoms begin. Some of these genes encode for different types of molecular machines whose normal job is to repair…
Drug to treat movement symptoms of HD approved by FDA
The vast majority of people with Huntington’s disease experience movement symptoms known as chorea. Valbenazine, also known as INGREZZA, has recently been approved by the…