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A road less traveled: how making less huntingtin can alter somatic instability and may delay symptoms
One mystery that many scientists think holds the key to curing HD is its mysterious age of onset. Although people with HD carry the expanded…
A tug-of-war at the DNA: how Huntington’s repeats grow and shrink
Ever since large genetic studies in Huntington’s disease (HD) revealed that the longer the CAG expansion, the earlier symptoms appear, we’ve known that repeat length…
UniQure Receives FDA Meeting Minutes on AMT-130 While Community Support Remains Strong
On December 4, 2025, uniQure announced they have received the final meeting minutes from their October 29 pre-Biologics License Application (BLA) meeting with the FDA…
Feeding the Brain Through the Gut: How Prebiotics Might Shape Huntington’s Disease
When it comes to thinking about the effects of Huntington’s disease (HD), most people automatically start to think about the brain due to the severe…
An Old Drug, New Tricks: Sertraline May Lighten the Load in HD by Targeting Protein Production
Depression and anxiety are common symptoms of Huntington’s disease (HD), and they can make everything harder. New research explores how sertraline, a widely-used antidepressant, affects…