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New insights into intermediate CAG repeats: Mapping the expansion continuum

Why do some people with intermediate CAG repeats, a genetic “gray zone” in Huntington’s disease, develop neurological symptoms while others do not? This article covers…

UniQure and FDA No Longer in Alignment on Approval Pathway for AMT-130

In a very brief press release from uniQure on November 3, 2025 we learned that the company is no longer aligned with the FDA on…

October 2025: This Month in Huntington’s Disease Research

This month brought new revelations across biomarkers, basic science and community gathering. In particular, we saw how DNA-repair targeting strategies are moving into focus, how…

A Map Through Time: Tracking Huntington’s Disease From Birth in the Brain

A new study in mouse models reveals how Huntington’s disease (HD) disrupts brain development over time, even long before symptoms appear. Using advanced sequencing tools…

Additional Clarity: What We Know 4 Weeks After the uniQure News

The past 4 weeks have been a whirlwind in the Huntington’s disease (HD) community. On September 25th we had an update from uniQure about a…

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