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2025: Year in Review
This was a year that tested the resilience of the Huntington’s disease (HD) community, with 2025 being remembered for landmark highs followed by disappointing lows…
Break Up With Your CAGs: How Three Letters Could Change Huntington’s Disease
Huntington’s disease (HD) is caused by a repeated stretch of the genetic letters C-A-G within the huntingtin (HTT) gene above a critical number. If the…
First participants dosed in new POINT-HD huntingtin-lowering trial
A new Huntington’s disease (HD) clinical trial has reached an important milestone: the first participants have now been dosed in POINT-HD, a Phase 1 study…
A road less traveled: how making less huntingtin can alter somatic instability and may delay symptoms
One mystery that many scientists think holds the key to curing HD is its mysterious age of onset. Although people with HD carry the expanded…
A tug-of-war at the DNA: how Huntington’s repeats grow and shrink
Ever since large genetic studies in Huntington’s disease (HD) revealed that the longer the CAG expansion, the earlier symptoms appear, we’ve known that repeat length…