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How many is too many? Exploring the toxic CAG threshold in the Huntington’s disease brain
Drug hunters have been particularly interested in the repeating C-A-G letters of genetic code that lead to Huntington’s disease (HD). The number of CAG repeats…
Cry your eyes out: detecting huntingtin in tears
A recently published collaboration between academic researchers and pharmaceutical companies was successful at detecting huntingtin in tears. The scientists were looking for a new, easy…
The director’s cut: how CAG repeats change the editing of genetic messages
Long repetitive sequences of C-A-G letters in the DNA code are associated with at least 12 genetic diseases, including Huntington’s disease (HD). A group of…
Understanding expansions at the single cell level
In two recent studies, researchers looked at how different parts of the brain are affected by CAG expansions in Huntington’s disease (HD) at the level…
Huntington’s Disease Therapeutics Conference 2024 – Day 2
HDBuzz is back for Day 2 of the CHDI HD Therapeutics Conference: Wednesday February 28th in Palm Springs, California. This article summarizes our real-time updates…